disulphide - PMC

Denis V. Sudarikov, Yulia V. Gyrdymova, Alexander V. Borisov, Julia M. Lukiyanova, Roman V. Rumyantcev, Oksana G. Shevchenko, Diana R. Baidamshina, Nargiza D. Zakarova, Airat R. Kayumov, Ekaterina O. Sinegubova, Alexandrina S. Volobueva, Vladimir V. Zarubaev, Svetlana A. Rubtsova

Molecules. 2022 Aug; 27(16): 5101. Published online 2022 Aug 10. doi: 10.3390/molecules27165101

PMCID:: PMC9416111

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From structure to redox: the diverse functional roles of disulfides and implications in disease

Tyler J. Bechtel, Eranthie Weerapana

Proteomics. Author manuscript; available in PMC 2017 Mar 27.

Published in final edited form as: Proteomics. 2017 Mar; 17(6): 10.1002/pmic.201600391. doi: 10.1002/pmic.201600391

PMCID:: PMC5367942

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Ultra-rapid glutathionylation of chymotrypsinogen in its molten globule-like conformation: A comparison to archaeal proteins

Alessio Bocedi, Giorgia Gambardella, Giada Cattani, Simonetta Bartolucci, Danila Limauro, Emilia Pedone, Federica Iavarone, Massimo Castagnola, Giorgio Ricci

Sci Rep. 2020; 10: 8943. Published online 2020 Jun 2. doi: 10.1038/s41598-020-65696-5

PMCID:: PMC7265447

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A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage

Xinming Li, Baoxin Zhang, Chaoxian Yan, Jin Li, Song Wang, Xiangxu Wei, Xiaoyan Jiang, Panpan Zhou, Jianguo Fang

Nat Commun. 2019; 10: 2745. Published online 2019 Jun 21. doi: 10.1038/s41467-019-10807-8

PMCID:: PMC6588570

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Chemistry and Enzymology of Disulfide Cross-linking in Proteins

Deborah Fass, Colin Thorpe

Chem Rev. Author manuscript; available in PMC 2019 Feb 14.

Published in final edited form as: Chem Rev. 2018 Feb 14; 118(3): 1169–1198. Published online 2017 Jul 12. doi: 10.1021/acs.chemrev.7b00123

PMCID:: PMC5808910

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The Role of Follicular Fluid Thiol/Disulphide Homeostasis in Polycystic Ovary Syndrome

Esra Nur Tola, Nadiye Köroğlu, Merve Ergin, Hilmi Baha Oral, Abdülkadir Turgut, Özcan Erel

Balkan Med J. 2018 Jul; 35(4): 306–310. Published online 2018 Jul 24. doi: 10.4274/balkanmedj.2017.1140

PMCID:: PMC6060971

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Evaluation of irreversible protein thermal inactivation caused by breakage of disulphide bonds using methanethiosulphonate

Junichiro Futami, Ai Miyamoto, Atsushi Hagimoto, Shigeyuki Suzuki, Midori Futami, Hiroko Tada

Sci Rep. 2017; 7: 12471. Published online 2017 Sep 29. doi: 10.1038/s41598-017-12748-y

PMCID:: PMC5622167

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Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition

Cynthia A. Danquah, Eleftheria Kakagianni, Proma Khondkar, Arundhati Maitra, Mukhlesur Rahman, Dimitrios Evangelopoulos, Timothy D. McHugh, Paul Stapleton, John Malkinson, Sanjib Bhakta, Simon Gibbons

Sci Rep. 2018; 8: 1150. Published online 2018 Jan 18. doi: 10.1038/s41598-017-18948-w

PMCID:: PMC5773482

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An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease

Veysel Agan, Hakim Celik, Mehmet Ali Eren, Fatma Zehra Agan, Ozcan Erel, Salim Neselioglu, Ismail Koyuncu, Ataman Gonel

Medicina (Kaunas) 2019 Jun; 55(6): 275. Published online 2019 Jun 14. doi: 10.3390/medicina55060275

PMCID:: PMC6630526

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Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER

Greg J Poet, Ojore BV Oka, Marcel van Lith, Zhenbo Cao, Philip J Robinson, Marie Anne Pringle, Elias SJ Arnér, Neil J Bulleid

EMBO J. 2017 Mar 1; 36(5): 693–702. Published online 2017 Jan 16. doi: 10.15252/embj.201695336

PMCID:: PMC5331760

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Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS

Fernanda A. Sala, Gareth S. A. Wright, Svetlana V. Antonyuk, Richard C. Garratt, S. Samar Hasnain

PLoS Biol. 2019 Feb; 17(2): e3000141. Published online 2019 Feb 8. doi: 10.1371/journal.pbio.3000141

PMCID:: PMC6383938

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Novel Roles of the Non-catalytic Elements of Yeast Protein-disulfide Isomerase in Its Interplay with Endoplasmic Reticulum Oxidoreductin 1

Yingbo Niu, Lihui Zhang, Jiaojiao Yu, Chih-chen Wang, Lei Wang

J Biol Chem. 2016 Apr 8; 291(15): 8283–8294. Published online 2016 Feb 4. doi: 10.1074/jbc.M115.694257

PMCID:: PMC4825027

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Evaluation of the radioprotective effects of thymoquinone on dynamic thiol-disulphide homeostasis during total-body irradiation in rats

Cigdem Damla Deniz, Meryem Aktan, Ozcan Erel, Mehmet Gurbilek, Mehmet Koc

J Radiat Res. 2019 Jan; 60(1): 23–28. Published online 2018 Oct 24. doi: 10.1093/jrr/rry083

PMCID:: PMC6373685

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Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers

Bahri Elmas, Mehmet Karacan, Pınar Dervişoğlu, Mustafa Kösecik, Şükriye Pınar İşgüven, Ceylan Bal

Anatol J Cardiol. 2017 Nov; 18(5): 361–369. Published online 2017 Jul 25. doi: 10.14744/AnatolJCardiol.2017.7740

PMCID:: PMC5731286

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Effects of Hemodialysis on Thiol-Disulphide Homeostasis in Critically Ill Pediatric Patients with Acute Kidney Injury

Ganime Ayar, Sanliay Sahin, Mutlu Uysal Yazici, Salim Neselioglu, Ozcan Erel, Umut Selda Bayrakcı

Biomed Res Int. 2018; 2018: 1898671. Published online 2018 Sep 25. doi: 10.1155/2018/1898671

PMCID:: PMC6176300

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Effects of antiviral drug therapy on dynamic thiol/disulphide homeostasis and nitric oxide levels in COVID-19 patients

Ayşe Özlem Mete, Kübra Koçak, Ahmet Saracaloglu, Seniz Demiryürek, Özgür Altınbaş, Abdullah T. Demiryürek

Eur J Pharmacol. 2021 Sep 15; 907: 174306. Published online 2021 Jul 7. doi: 10.1016/j.ejphar.2021.174306

PMCID:: PMC8262407

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Role of Cell Surface Lipids and Thiol-Disulphide Exchange Pathways in Regulating the Encryption and Decryption of Tissue Factor

Shabbir A. Ansari, Usha R. Pendurthi, L. Vijaya Mohan Rao

Thromb Haemost. Author manuscript; available in PMC 2021 Jan 13.

Published in final edited form as: Thromb Haemost. 2019 Jun; 119(6): 860–870. Published online 2019 Mar 12. doi: 10.1055/s-0039-1681102

PMCID:: PMC7805104

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Four thiol-oxidoreductases involved in the formation of disulphide bonds in the Streptomyces lividans TK21 secretory proteins

Sonia Gullón, Silvia Marín, Rafael P. Mellado

Microb Cell Fact. 2019; 18: 126. Published online 2019 Jul 25. doi: 10.1186/s12934-019-1175-0

PMCID:: PMC6657201

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PMC Images search for disulphide

Figure 4Disulphide bridges of V HH domains with additional disulphide bonds.

(A) Conserved disulphide bond in type 1 V _HH domains (B) Non conserved disulphide bonds in type 1 V _HH domains, (C) Conserved disulphide bond in type 2 V _HH domains and (D) non-conserved disulphide bonds in type 2 V _HH domains. The disulphide bridges are indicated in yellow connecting any two cysteines.

Discrete analysis of camelid variable domains: sequences, structures, and in-silico structure prediction

PeerJ. 2020;8:e8408.
Figure 6Schematic model for the ERp57-mediated disulphide exchange which favors bacterial attachment to epithelial cells.

We suggest that membrane-associated ERp57 (PDI) (panel a) catalyzes a disulphide exchange reaction between a surface exposed Burkholderia cenocepacia receptor (BcR) and a disulphide bond located on a B. cenocepacia (Bc) solvent exposed protein. We hypothesize that the formation of a transient disulphide bond between ERp57 and a BcR located on the cell membrane (panel b) promotes B. cenocepacia adhesion to the cell surface (panel c) and the subsequent internalization of the bacterium.

An ERp57-mediated disulphide exchange promotes the interaction between Burkholderia cenocepacia and epithelial respiratory cells

Sci Rep. 2016;6:21140.
Fig. 5Cyclisation through disulphide bonds. (a) A disulphide bond is formed and cleaved under oxidative and reductive conditions, respectively. (b) Orthogonal disulphide pairing using the CXC motif (X = any amino acid), which does not form a disulphide bond between two Cys residues separated by one amino acid. (c) In the presence of penicillamine (Pen) residues, Pen and Cys form thermodynamically more stable mixed disulphide bonds. (d) Use of an unnatural dithiol amino acid, Dtaa, to moderate the number of possible disulphide patterns. (e) A thiol-containing molecule can react with a disulphide molecule via the thiol-disulphide exchange reaction. (f) Disulphide stapling reagents that react with two Cys residues and form a stable covalent adduct. Selected stapling reagents are shown on the right.

Approaches for peptide and protein cyclisation

Org Biomol Chem. 2021 May 12;19(18):3983-4001.
Figure 9

Illustration of distinct disulphide bond annotation in Ribonuclease A-like [SCOP family code: d.5.1.1] family of proteins. The structural alignment contains sixteen members. Marking of the disulphide bond positions on the structure based multiple sequence alignment has resulted in five distinct structural positions. However the maximum number of disulphides in a family member is only four, while the minimum is three. Each distinct disulphide bond is represented with approximate positions of their cysteines in the alignment. In the zoom out of the alignment region of the 4th distinct disulphide bond note the first cysteine is not in equivalent position, nevertheless it is conserved. Applying relaxation brings this disulphide bond into conservation. Also notice that this disulphide bond is not conserved in all the members.

Analysis on conservation of disulphide bonds and their structural features in homologous protein domain families

BMC Struct Biol. 2008;8:55-55.